Evidence map›Paper›PMID 42867110›Full record

ArticleAnnals of clinical and translational neurology2026

Stage-Specific Patterns of Imaging and Non-Motor Biomarkers in Spinocerebellar Ataxia Type 3.

Chun Li, Zhi-Xian Ye, Xuan-Yu Chen, Liang-Liang Qiu, Zhi-Li Chen, Yu-Sen Qiu, Wei Lin, Ru-Ying Yuan, Xin-Tong Yu, Chun-Yu Huang and 8 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04010214 (A Registered Cohort Study on Cerebellar Ataxia), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04010214 recruitingnot on this map

A Registered Cohort Study on Cerebellar Ataxia

TypeobservationalSponsorNing Wang, MD., PhD.Ran2019 to 2059Enrolled1,500ConditionsCerebellar AtaxiaArmsNo intervention
3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Chun LiDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Zhi-Xian YeDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Xuan-Yu ChenDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Liang-Liang QiuDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Zhi-Li ChenDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Yu-Sen QiuDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Wei LinDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Ru-Ying YuanDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Xin-Tong YuDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Chun-Yu HuangDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Xin-Yuan ChenDepartment of Rehabilitation Medicine of First Affiliated Hospital, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0002-3241-6719
Min-Ting LinDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Jian-Ping HuDepartment of Radiology of First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Wan-Jin ChenDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0002-9472-8494
Ning WangDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0002-9655-9735
Shao-Bo YaoDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0003-2245-871X
Shi-Rui GanDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0001-7552-5141
Ying FuDepartment of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0002-1590-3945

Funding

National Natural Science Foundation of China 82230039National Natural Science Foundation of China 82371349National Natural Science Foundation of China 82371879National Natural Science Foundation of China U21A20360the Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province 2022ZQNZD005
6 · The paper itself

Abstract

objectiveAdvancements in disease-modifying therapies for spinocerebellar ataxia Type 3 (SCA3) underscore the need for robust biomarkers to monitor disease progression and evaluate treatment efficacy. Although motor phenotypes have been well characterized, less is known about non-motor and imaging-based features across different disease stages. This study aimed to characterize stage-specific patterns of non-motor and imaging biomarkers in SCA3.

methodsThis cross-observational study included 229 patients with SCA3 and 104 age- and sex-matched healthy controls from the Organization for Southeast China for cerebellar ataxia research. Non-motor symptoms were assessed using a battery of neuropsychological tests. Brain volume loss was assessed by 3.0-Tesla MRI with regions-of-interest (ROI)-based volumetric analysis. Neuroinflammation was quantified in vivo using translocator protein positron emission tomography (TSPO-PET) with the

resultsNon-motor symptoms, including cognitive functions, anxiety, fatigue, depression, and sleep quality, declined after ataxia onset in SCA3. Volume loss in the brainstem and ventral diencephalon diverged from normal controls at 0.7 and 0.2 years before ataxia onset, respectively. Correspondingly, the TSPO signal in the brainstem and ventral diencephalon increased and deviated from normal throughout the disease course.

interpretationOur findings propose a staging model of SCA3 that includes a biomarker stage characterized by multidimensional objective indicators of neurodegeneration and neuroinflammation from pre-ataxia to ataxia onset.

trial registrationClinicalTrials.gov identifier: NCT04010214.

Indexed as

biomarkersMRIspinocerebellar ataxia Type 3TSPO‐PET

Identifiers

PMID42867110
PMCPMC13660296

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