Evidence map›Paper›PMID 42867075›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Structured exercise, cognitive-social engagement, and cognitive impairment-free life expectancy across four longitudinal aging cohorts.

Xiangwei Li, Ying Liu, Junyu Sun, Hui Zhang, Yaqian Xu, Chongyu Ding, Yanting Zhang, Tianlang Tong, Zhaojun Wang, Wei Lyu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiangwei Li *School of Global Health, Chinese Centre for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying Liu *China Academy of Chinese Medical Sciences, Beijing, China.
Junyu SunInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Hui ZhangSchool of Global Health, Chinese Centre for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yaqian XuSchool of Global Health, Chinese Centre for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chongyu DingSchool of Global Health, Chinese Centre for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanting ZhangHainan International Medical Center, Shanghai Jiao Tong University School of Medicine, Hainan, China.
Tianlang TongHainan International Medical Center, Shanghai Jiao Tong University School of Medicine, Hainan, China.
Zhaojun WangSchool of Global Health, Chinese Centre for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei LyuDepartment of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Xian CuiDiagnostic Imaging Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

Hainan Provincial Natural Science Foundation of China 326MS0435National Natural Science Foundation of China 82574160School of Medicine, Shanghai Jiao Tong University KJ2-0112-23-0002
6 · The paper itself

Abstract

introductionWhether cognitive-social engagement can compensate for insufficient structured exercise in cognitive aging remains unclear.

methodsWe harmonized repeated data from four aging cohorts across Asia, North America, and Europe. Structured exercise and cognitive-social engagement were cross-classified at each wave into low-low (LL), high exercise-low engagement (HL), low exercise-high engagement (LH), and high-high (HH). Cohort-specific Cox models and multistate life tables estimated incident cognitive impairment and cognitive impairment-free life expectancy.

resultsCognitive impairment-free life expectancy from age 50 was 17.5, 23.2, 20.1, and 24.7 years for the low exercise + low cognitive-social engagement (LL), high exercise + low cognitive-social engagement (HL), low exercise + high cognitive-social engagement (LH), and high exercise + high cognitive-social engagement (HH) groups, respectively. DISCUSSION: Structured exercise and cognitive-social engagement showed combined, non-interchangeable benefits for cognitive aging. These findings support integrated lifestyle strategies for dementia prevention across diverse aging populations, health systems, and prevention settings worldwide.

Indexed as

AgingCognitionCognitive AgingCognitive DysfunctionExerciseLife ExpectancyAgedAsiaEuropeFemaleHumansLongitudinal StudiesMaleNorth Americaaging cohortscognitive agingcognitive impairmentcognitive–social engagementlife expectancymultistate life tablestructured exercise

Identifiers

PMID42867075
PMCPMC13659936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.