ArticleHypertension (Dallas, Tex. : 1979)2026
Aldosterone-Producing Lesions Harboring
Peeradon Vibhatavata, Yueting Liu, Madson Q Almeida, Laurence Amar, Irina Bancos, Stephanie Baron, Frederike Butz, Debbie L Cohen, Silas A Culver, Fabio Luiz Fernandes-Rosa and 25 more
Abstract read
In one paragraphArticle in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
35 authors.
Peeradon VibhatavataDivision of Metabolism, Endocrinology, and Diabetes (P.V., Y.L., W.E.R., A.F.T.), University of Michigan, Ann Arbor.ORCID 0009-0008-3845-1970 Yueting LiuDivision of Metabolism, Endocrinology, and Diabetes (P.V., Y.L., W.E.R., A.F.T.), University of Michigan, Ann Arbor.ORCID 0000-0002-1922-0244 Madson Q AlmeidaUnidade de Adrenal, Laboratório de Endocrinologia Molecular e Celular LIM25, Divisão de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Brazil (M.Q.A., A.G.G.).ORCID 0000-0002-2957-6148 Laurence AmarHypertension Unit, AP-HP, Hôpital Européen Georges Pompidou, Paris, France (L.A., B.P.).ORCID 0000-0003-3942-4276 Irina BancosDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester (I.B., W.F.Y.).ORCID 0000-0001-9332-2524 Frederike ButzDepartment of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (F.B.).ORCID 0000-0002-5963-1558 Debbie L CohenDepartment of Medicine, Renal, Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.L.C.).ORCID 0000-0002-1325-315X Silas A CulverDivision of Endocrinology and Metabolism, University of Virginia Health System, Charlottesville (S.A.C.).
Fabio Luiz Fernandes-RosaUniversité Paris Cité, PARCC, Inserm, Paris, France (S.B., F.L.F.-R., M.-C.Z.).ORCID 0000-0002-0162-0792 Augusto G GuimaraesUnidade de Adrenal, Laboratório de Endocrinologia Molecular e Celular LIM25, Divisão de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Brazil (M.Q.A., A.G.G.).ORCID 0000-0001-5642-0125 Amir H HamrahianDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore (A.H.H.).ORCID 0000-0001-8832-9385 Jinbo HuDepartment of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, China (J.H.).ORCID 0000-0003-2925-0583 Markus KroissDepartment of Medicine IV, LMU University Hospital, LMU Munich, Germany (M.K., M.F.O.).
James M LutherDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville (J.M.L.).ORCID 0000-0001-7225-2897 Matthias F OettleDepartment of Medicine IV, LMU University Hospital, LMU Munich, Germany (M.K., M.F.O.).ORCID 0009-0003-9419-9750 Benjamin ParienteHypertension Unit, AP-HP, Hôpital Européen Georges Pompidou, Paris, France (L.A., B.P.).ORCID 0009-0001-6164-5449 Juilee RegeDepartment of Molecular & Integrative Physiology (J.R., W.E.R.), University of Michigan, Ann Arbor.ORCID 0000-0003-2593-5008 Fumitoshi SatohDepartment of Nephrology and Hypertension, Tohoku University Hospital, Sendai, Miyagi, Japan (F.S., W.E.R.).ORCID 0000-0003-0720-0470 Ute SchollCenter of Genomic Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Germany (U.S.).ORCID 0000-0002-0309-8045 Michael StowasserEndocrine Hypertension Research Centre, University of Queensland Frazer Institute, Princess Alexandra Hospital, Brisbane, Australia (M.S.).ORCID 0000-0002-4317-8584 Yuta TezukaDepartment of Diabetes, Metabolism, and Endocrinology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan (Y.T.).ORCID 0000-0003-1546-6949 Aaron M UdagerDepartment of Pathology (A.M.U.), University of Michigan, Ann Arbor.
Anand VaidyaDivision of Endocrinology, Diabetes, and Hypertension, Center for Adrenal Disorders, Mass General Brigham and Harvard Medical School, Boston, MA (A.V.).ORCID 0000-0002-0314-9252 Desmaré van RooyenDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor (D.v.R., C.-Y.W.).ORCID 0000-0003-2969-1127 Heather WachtelDepartment of Surgery, University of Pennsylvania Health System, Philadelphia (H.W.).ORCID 0000-0003-3786-3638 Vin-Cent WuDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei (V.-C.W.).ORCID 0000-0001-7935-0991 Chun-Yi WuDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor (D.v.R., C.-Y.W.).
Maria-Christina ZennaroUniversité Paris Cité, PARCC, Inserm, Paris, France (S.B., F.L.F.-R., M.-C.Z.).ORCID 0000-0001-5449-9191 William F YoungDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester (I.B., W.F.Y.).ORCID 0000-0001-5481-4884 William E RaineyDivision of Metabolism, Endocrinology, and Diabetes (P.V., Y.L., W.E.R., A.F.T.), University of Michigan, Ann Arbor.
Adina F TurcuDivision of Metabolism, Endocrinology, and Diabetes (P.V., Y.L., W.E.R., A.F.T.), University of Michigan, Ann Arbor.ORCID 0000-0001-9831-6190 Funding
Primary Aldosteronism Subtypes: Pathophysiology and Steroid SignaturesR01HL155834 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TURCU, ADINA F · 2021 to 2025
$3.5M11-Oxyandrogens and Aging: Health ImplicationsR01AG080516 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Adina F Turcu · 2023 to 2026
$2.3MA genotype-phenotype study of germline succinate dehydrogenase pathogenic variantsK08CA270385 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Heather Wachtel · 2022 to 2026
$967kNCI NIH HHS K08 CA270385NHLBI NIH HHS R01 HL155834NIA NIH HHS R01 AG080516
6 · The paper itselfAbstract
backgroundSomatic aldosterone-driver mutations are identified in >90% of patients with primary aldosteronism undergoing adrenalectomy, and they display distinct demographic clustering.
methodsThis international collaboration of 16 centers included patients with primary aldosteronism harboring pathogenic variants in
resultsWe included 300 patients (mean age, 57±11 years; 85% men) with aldosterone-producing lesions harboring
conclusions
Indexed as
adrenal cortexadrenal glandsadrenal neoplasmaldosteronehyperaldosteronismhypertension
Identifiers
PMID42866865
PMCPMC13685462
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