ArticleGland surgery2026
Prognostic factors in thyroid cancer with lung-only metastasis: SEER-based retrospective study.
Article in Gland surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Lung-only metastasis in thyroid cancer is uncommon, and its prognostic determinants remain poorly defined. This study aimed to investigate the clinicopathological features and prognostic factors associated with survival in patients with primary thyroid cancer with lung-only metastases (PTCSLMs). Methods: Patients diagnosed with PTCSLMs from 2010 to 2015 were screened from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database. Inclusion criteria comprised histologically confirmed thyroid cancer, first primary malignancy, and lung‑only metastasis at initial diagnosis, while patients with bone/liver/brain metastases, unknown race, unknown T stage/T Results: A total of 592 patients diagnosed with PTCSLMs from 2010 to 2015 were extracted from the SEER database based on the specified criteria for inclusion and exclusion. Univariate analysis demonstrated statistically significant associations between OS and age at diagnosis, marital status, histologic subtype, T stage, N stage, grade stage, surgery, radiotherapy and chemotherapy (P Conclusions: Our study suggested that the higher age at diagnosis and higher pathological grade were correlated with worse prognosis. In contrast, surgery, radiotherapy and chemotherapy showed a favorable prognostic association. Age at diagnosis, histological type, T stage, grade stage, surgery, radiotherapy and chemotherapy are associated with prognosis and they are independent prognostic factors for PTCSLMs.
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