Evidence map›Paper›PMID 42866781›Full record

ArticleAnnals of medicine and surgery (2012)2026

Association between serum 25-hydroxyvitamin D and osteoarthritis prevalence in US adults: a cross-sectional study using NHANES 2007-2023.

Ibrahim Khalil, Mohammed Hrebat, Nadjet Laouadi, Ahmed Osman Hassan Ali, Tareq Albaqali, Mahmoud Ali Khazbak, Meera Abu Eisheh, Mahmoud Raed Sarahen, Taher Abuawwad, Farrukh Ameer and 5 more

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Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ibrahim KhalilDepartment of Emergency Medicine, Red Crescent Specialized Hospital, Hebron, Palestine.ORCID https://orcid.org/0009-0001-4479-2316
Mohammed HrebatFaculty of Medicine, Tanta University, Tanta, Egypt.
Nadjet LaouadiCardiac Anesthesia Consultant, Heart Center, Aljouf Health Cluster, Al-Jouf, Saudi Arabia.
Ahmed Osman Hassan AliCritical Care Department, Dr. Soliman Fakeeh Hospital, Riyadh, Saudi Arabia.
Tareq AlbaqaliFaculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Mahmoud Ali KhazbakDirectorate General of Health Services, Oman Ministry of Health, Muscat, Oman.
Meera Abu EishehPalestine Polytechnic University, Hebron, Palestine.
Mahmoud Raed SarahenFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Taher AbuawwadSchool of Medicine, Fujian Medical University, Fuzhou, China.
Farrukh AmeerDepartment of Adult Cardiology, Dr. Soliman Fakeeh Hospital, Fakeeh Care Group, Riyadh, Saudi Arabia.
Bilal AqelFaculty of Medicine, Al-Quds University, Jerusalem, Palestine.
Mohammad HujeiratDepartment of Internal Medicine, Chaim Sheba Medical Center at Tel HaShomer, Ramat Gan, Israel.
Manar AtrashPalestine Polytechnic University, Hebron, Palestine.
Noor Nader RashedAn-Najah National University, Nablus, Palestine.
Ahmed AbdelsamadDepartment of Surgery II, University of Witten/Herdecke - Knappschaft Klinikum Recklinghausen, Recklinghausen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a leading cause of chronic disability globally, and the role of vitamin D in OA pathogenesis remains controversial. This cross-sectional study analyzed data from 35 887 US adults aged ≥20 years across seven NHANES cycles (2007-2023), all using standardized LC-MS/MS for serum 25-hydroxyvitamin D [25(OH)D] measurement. Survey-weighted logistic regression, restricted cubic splines (RCS), subgroup analyses with interaction testing, E-value assessment, Baron-Kenny CRP mediation analysis, and temporal trend evaluation were performed. The survey-weighted OA prevalence was 26.2%. In the fully adjusted model, each 10 nmol/L increase in 25(OH)D was associated with 5.3% higher odds of OA (OR = 1.053; 95% CI: 1.037-1.069;

Indexed as

25-hydroxyvitamin Dcross-sectional studydose-responseNHANESosteoarthritisrestricted cubic splinesvitamin D

Identifiers

PMID42866781
PMCPMC13657557

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.