ArticleAnnals of medicine and surgery (2012)2026
Cumulative obesity exposure and hepato-pancreato-biliary cancer risk following different weight-loss interventions: retrospective cohort study.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Obesity is a time-dependent carcinogenic exposure associated with an increased risk of hepatopancreatobiliary (HPB) cancers. Although weight-loss interventions improve metabolic status, the comparative oncologic impact and the role of cumulative obesity duration remain unclear. Objectives: To compare HPB cancer incidence across lifestyle-based, pharmacologic, and surgical weight-loss strategies and to assess whether differences in cumulative obesity exposure before and after weight reduction may influence cancer risk. Setting: A retrospective cohort study at a tertiary university hospital in Israel. Methods: We analyzed 1131 adults who achieved weight loss between 2010 and 2024 through lifestyle modification, weight-loss medications, or bariatric surgery. For each patient, the duration of obesity before and after weight loss, the magnitude of BMI reduction, and follow-up intervals were recorded. HPB cancers - including hepatocellular carcinoma, pancreatic ductal adenocarcinoma, cholangiocarcinoma, and gallbladder carcinoma - were identified through national registry linkage. Group differences were evaluated using analysis of variance, Kruskal-Wallis, χ Results: Twenty-seven HPB cancers were identified. Incidence did not differ significantly among lifestyle (2.05%), medication-induced (3.24%), and surgery-induced (1.05%) groups ( Conclusions: Although no statistically significant differences in HPB cancer incidence were observed among weight-loss strategies, exploratory numerical differences were noted, with the lowest crude incidence in the bariatric surgery group. Given the limited number of events, these findings should be interpreted cautiously and viewed as hypothesis-generating only. Further adequately powered prospective studies are required before any clinical inference can be made.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.