A comparative study of the efficacy of apitoxin gel versus photobiomodulation by diode laser for recurrent aphthous stomatitis treatment.

Mohamed Omar Elboraey, Sherouk Mohamed Mohamed Gamal, Reda Saber Sabra, Mostafa I Fayad, Abdullah Alqhtani, Rayan Meer

Registry-linked trialAbstract read

In one paragraph

Article in Journal of Taibah University Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07135609 (Apitoxin Versus Soft Laser for Management of Aphthous Ulceration), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07135609 nacompletednot on this map

Apitoxin Versus Soft Laser for Management of Aphthous Ulceration

TypeinterventionalSponsorTanta UniversityRan2024 to 2025Enrolled60ConditionsApitoxin, Bee Venom Therapy, Management, Aphthous UlcerationArmsLow-level laser therapy (LLLT), Apitoxin

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed Omar ElboraeyDepartment of Preventive Dental Sciences, College of Dentistry, Taibah University, Al-Madinah Al-Munawwarah, KSA.

Sherouk Mohamed Mohamed GamalPeriodontology, Oral Diagnosis and Oral Radiology Department, Faculty of Dentistry, Tanta, University, Tanta, Egypt.

Reda Saber SabraPeriodontology, Oral Diagnosis and Oral Radiology Department, Faculty of Dentistry, Tanta, University, Tanta, Egypt.

Mostafa I FayadDepartment of Substitutive Dental Science, College of Dentistry, Taibah University, Almadinah Almunawwarah, KSA.

Abdullah AlqhtaniDepartment of Preventive Dental Sciences, College of Dentistry, Taibah University, Al-Madinah Al-Munawwarah, KSA.

Rayan MeerDepartment of Preventive Dental Sciences, College of Dentistry, Taibah University, Al-Madinah Al-Munawwarah, KSA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bee venom (apitoxin) contains bioactive compounds. Diode laser irradiation has a photobiomodulation effect. Both modalities are considered potential alternative therapies for managing recurrent aphthous stomatitis (RAS). Objective: This study compared the therapeutic effectiveness and safety of apitoxin gel versus photobiomodulation therapy (PBM) for the management of recurrent aphthous ulcers. Methods: Sixty participants with symptomatic recurrent aphthous ulcer ≥4 mm were randomly allocated to two groups. Group I was managed by PBM and group II by using 0.3% apitoxin gel. The pain sensation score measured using a visual analog scale (VAS), and the ulcer surface area and ulcer depth were recorded at baseline and on day 5. The effectiveness index (EI) for pain improvement was calculated for each patient. Results: The Shapiro-Wilk test was applied to verify the normality of distributions using IBM SPSS software package version 24.0. The independent-samples Conclusion: Apitoxin gel reduces pain, speeds healing, and controls inflammation in RAS. Its effects are due to anti-inflammatory, antioxidant, and antimicrobial activities, and it may provide a more cost-effective and convenient option for patients. Trial registration: ClinicalTrials.gov, TRN: NCT07135609.

Indexed as

ApitoxinBee venom therapyDentistryPhotobiomodulation therapyRecurrent aphthous stomatitis

Identifiers

PMID42866728

DOI10.1016/j.jtumed.2026.09.007

PMCPMC13657375

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

NCT07135609ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.