ArticleAnnals of medicine and surgery (2012)2026
The triglyceride-glucose index as a predictor of cardiovascular disease: an umbrella review of meta-analyses.
Article in Annals of medicine and surgery (2012), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
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Abstract
Background: The triglyceride-glucose (TyG) index has gained recognition as a tool for assessing cardiovascular disease risk. This umbrella review synthesized findings from multiple meta-analyses examining the association between the TyG index and cardiovascular outcomes. Methods: In this umbrella review of meta-analyses, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: A higher TyG index was associated with increased odds of arterial stiffness [categorical: odds ratio (OR) = 1.83, 95% confidence interval (CI): 1.55-2.17, Conclusion: Current meta-analytic evidence suggests that higher TyG index values are associated with several adverse cardiovascular outcomes. However, substantial heterogeneity and the generally low methodological quality of the included meta-analyses limit confidence in the magnitude and clinical applicability of these associations. The TyG index may serve as an adjunctive cardiovascular risk marker, but further high-quality prospective validation is required before routine clinical implementation.
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