Evidence map›Paper›PMID 42866687›Full record

ArticleiScience2026

Topical application of urolithin A activates mitophagy and enhances mitochondrial function to promote skin longevity.

Davide D'Amico, Julie Faitg, Frédéric Amaral, Carine Ballihaut, Andréane M Fouassier, Charlotte Tissot, Isha Rana, Julien Laboureau, Natascha Hennighausen, Marianne Brandt and 9 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Davide D'AmicoAmazentis SA (Timeline), EPFL Innovation Park, 1015 Lausanne, Switzerland.
Julie FaitgAmazentis SA (Timeline), EPFL Innovation Park, 1015 Lausanne, Switzerland.
Frédéric AmaralL'Oréal R&I, Clichy, France.
Carine BallihautL'Oréal R&I, Clichy, France.
Andréane M FouassierAmazentis SA (Timeline), EPFL Innovation Park, 1015 Lausanne, Switzerland.
Charlotte TissotAmazentis SA (Timeline), EPFL Innovation Park, 1015 Lausanne, Switzerland.
Isha RanaAmazentis SA (Timeline), EPFL Innovation Park, 1015 Lausanne, Switzerland.
Julien LaboureauAmazentis SA (Timeline), EPFL Innovation Park, 1015 Lausanne, Switzerland.
Natascha HennighausenSGS Proderm GmbH, Hamburg, Germany.
Marianne BrandtSGS Proderm GmbH, Hamburg, Germany.
Nicholas KronGenevia Technologies OY, 33100 Tampere, Finland.
Xavier MaratL'Oréal R&I, Clichy, France.
Chantal JouyL'Oréal R&I, Clichy, France.
Annie F BlackLancôme, 62 Quai Charles Pasqua, 92300 Levallois Perret, France.
Gayané AzadiguianLancôme, 62 Quai Charles Pasqua, 92300 Levallois Perret, France.
Delphine GuillonL'Oréal R&I, Clichy, France.
Jean-Thierry SimonnetL'Oréal R&I, Clichy, France.
Chris RinschAmazentis SA (Timeline), EPFL Innovation Park, 1015 Lausanne, Switzerland.
Anurag SinghAmazentis SA (Timeline), EPFL Innovation Park, 1015 Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urolithin A (UA, Mitopure), a postbiotic that promotes mitophagy and mitochondrial function following oral administration, was evaluated for its effects on skin health in human skin models and when applied topically to healthy subjects in randomized clinical studies. UA tested in 2D and 3D reconstructed human skin and

Indexed as

collagen IIIcollagen VIIelastinfilaggrininflammationKi-67mitochondriamitophagyskin agingurolithin A

Identifiers

PMID42866687
PMCPMC13657230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.