ArticleAdvances in radiation oncology2026
Comparative Outcomes of Single- and Split-Fraction Low-Dose Radiation in Mycosis Fungoides.
Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Purpose: Localized radiation is a cornerstone therapy for early-stage mycosis fungoides (MF), with low-dose regimens achieving high response rates. However, the optimal fractionation schedule remains unclear. Single-fraction (8 Gy × 1) and split-fraction (4 Gy × 2) regimens are widely used, but comparative data are limited. Reducing treatment burden may be particularly important in rural settings, where travel distance can limit access. Methods and Materials: This study aims to compare lesion-level response, recurrence, and durability between 8 Gy × 1 and 4 Gy × 2 low-dose radiation regimens in MF. We performed a retrospective review of 136 lesions from 27 adults with biopsy-confirmed MF treated with localized electron beam radiation at a rural multidisciplinary cutaneous lymphoma clinic (2014-2025). Lesions were categorized as patch or plaque. The primary outcome was complete response (CR) at 6 months. Secondary outcomes included overall response rate, local recurrence, time to next therapy, and toxicity. Analyses included χ²/Fisher's exact tests, Kaplan-Meier survival, Cox regression, and inverse-probability weighting. Results: Of 136 lesions, 119 (87.5%) received 4 Gy × 2 and 17 (12.5%) received 8 Gy × 1. Six-month CR was 81.5% versus 82.4%, respectively ( Conclusions: Limitations of this study include retrospective design and small single-fraction sample. Single-fraction 8 Gy was associated with similar short-term outcomes and excellent tolerability, supporting its use as an effective, logistically advantageous option, particularly in rural practice.
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