Evidence map›Paper›PMID 42866606›Full record

ArticleiScience2026

Pharmacological protection from a sugar-rich diet through inhibition of Ras/MAPK signaling.

Mihails Laskovs, Jacob S Cook, Andrew R Pitt, Corinne M Spickett, Cathy Slack

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mihails LaskovsSchool of Medicine, Pharmacy and Biosciences & Aston Institute for Membrane Excellence, Aston University, Birmingham B4 7ET, UK.
Jacob S CookSchool of Medicine, Pharmacy and Biosciences & Aston Institute for Membrane Excellence, Aston University, Birmingham B4 7ET, UK.
Andrew R PittSchool of Medicine, Pharmacy and Biosciences & Aston Institute for Membrane Excellence, Aston University, Birmingham B4 7ET, UK.
Corinne M SpickettSchool of Medicine, Pharmacy and Biosciences & Aston Institute for Membrane Excellence, Aston University, Birmingham B4 7ET, UK.
Cathy SlackSchool of Medicine, Pharmacy and Biosciences & Aston Institute for Membrane Excellence, Aston University, Birmingham B4 7ET, UK.

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537
6 · The paper itself

Abstract

Consumption of sugar-rich diets adversely affects health and reduces life expectancy through the excessive production and storage of triacylglycerides (TAGs), leading to metabolic dysfunction. Here, we show that in

Indexed as

DrosophilalifespanlipidomicsmetabolismRas/MAPK signaling

Identifiers

PMID42866606
PMCPMC13657105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.