Evidence map›Paper›PMID 42866593›Full record

ArticleMaterials today. Bio2026

Adhesive cationic hyaluronic acid loading with small extracellular vesicles from IL-6 activated mesenchymal stem cells improves repair of corrosive esophageal injury.

Dan Luo, Shixian Li, Jianhong Sun, Shaolong Zheng, Zhengkui Huang, Na Xiang, Shan Guo, Zhi Yu, Hong Mei, Na Xu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dan LuoDepartment of Gastroenterology, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430015, PR China.
Shixian LiCollege of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, PR China.
Jianhong SunCollege of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, PR China.
Shaolong ZhengState Key Laboratory of Virology and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, PR China.
Zhengkui HuangRadiographic Center, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, 430015, PR China.
Na XiangCollege of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, PR China.
Shan GuoDepartment of Gastroenterology, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430015, PR China.
Zhi YuDepartment of Gastroenterology, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430015, PR China.
Hong MeiDepartment of Gastroenterology, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430015, PR China.
Na XuCollege of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, 430065, PR China.
Xiaohui SongDepartment of Obstetrics, Wuhan Children's Hospital, Wuhan Maternal and Child Healthcare Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430015, PR China.
Baoxiang WangDepartment of Gastroenterology, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430015, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of corrosive esophageal injury (CEI) remains challenging due to recurrent courses, frequent complications, and severe tissue damage. Enhancing the therapeutic potential of mesenchymal stem cell-derived small extracellular vesicles (sEVs) through cytokine preconditioning has emerged as a promising strategy. In this study, functionally enhanced sEVs (E-sEVs) were generated by pretreating umbilical cord-derived mesenchymal stem cells with interleukin-6 (IL-6). E-sEVs exhibited superior capabilities in promoting fibroblast migration and suppressing macrophage-mediated inflammation compared to naïve sEVs. To improve local retention and therapeutic efficacy, E-sEVs were integrated into a cationic hyaluronic acid (CHA) hydrogel with strong bioadhesive properties, forming a composite system termed E-sEVs@CHA. In vitro assays demonstrated that E-sEVs@CHA effectively promoted endothelial cell invasion, exhibited antioxidant activity, and modulated macrophage polarization toward an anti-inflammatory phenotype. In a rat model of CEI, E-sEVs@CHA significantly reduced esophageal inflammation, oxidative stress, and fibrotic remodeling, leading to improved tissue repair and reduced stricture formation. This study presents a novel cell-free therapeutic strategy with translational potential for the management of corrosive esophageal injury.

Indexed as

Corrosive esophageal injuryExosomeExtracellular vesiclesHyaluronic acidMesenchymal stem cells

Identifiers

PMID42866593
PMCPMC13656951

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.