ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2026
A tributyrin-monolaurin complex protects piglets against PEDV infection via viral inhibition, lipid metabolism restoration, and microbiota modulation.
Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Porcine epidemic diarrhea virus (PEDV) is a major pathogen causing severe diarrhea and intestinal damage in piglets. Monolaurin (GML) and tributyrin (TB) are well-documented functional lipids with intestinal health benefits, but their combined efficacy against PEDV infection remains unclear. The present study first investigated the anti-PEDV effect of GML, TB, and their mixtures using PEDV-infected Vero cells. Then, the effects of a microencapsulated TB-GML complex (PE) were evaluated in PEDV-infected piglets, focusing on its protective mechanisms. Vero cells were simultaneously treated with PEDV and graded concentrations of GML (20-40 μmol/L), TB (0.25-0.50 mmol/L), or their combinations to determine for synergistic antiviral effects. In vivo, a total of 30 piglets (2.49 ± 0.38 kg), 7-d-old, were randomly assigned to three groups: negative control (NC), PEDV, and PE + PEDV. After a 3-d adaptation period, piglets in the PE + PEDV group received an oral dose of PE at 100 mg/kg body weight for 7 consecutive days. On d 8, piglets in the PEDV and PE + PEDV groups were orally inoculated with 1 × 10
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