Evidence map›Paper›PMID 42866577›Full record

ArticleIJTLD open2026

The burden of multimorbidity in patients with TB-HIV: a retrospective cohort analysis.

K J Hill, N C Owaro, C Sekaggya-Wiltshire, P Mubiri, E L A Odongpiny, J Matovu, L Alinaitwe, F Aber, S Mpagama, S E Mills and 2 more

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Article in IJTLD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

K J HillInfection and Global Health Department, School of Medicine, University of St Andrews, St Andrews, UK.
N C OwaroInfectious Diseases Institute, Makerere University, Kampala, Uganda.
C Sekaggya-WiltshireInfection and Global Health Department, School of Medicine, University of St Andrews, St Andrews, UK.
P MubiriInfectious Diseases Institute, Makerere University, Kampala, Uganda.
E L A OdongpinyInfection and Global Health Department, School of Medicine, University of St Andrews, St Andrews, UK.
J MatovuInfectious Diseases Institute, Makerere University, Kampala, Uganda.
L AlinaitweInfectious Diseases Institute, Makerere University, Kampala, Uganda.
F AberInfectious Diseases Institute, Makerere University, Kampala, Uganda.
S MpagamaKibong'oto Infectious Diseases Hospital, Sanya Juu, Tanzania.
S E MillsInfection and Global Health Department, School of Medicine, University of St Andrews, St Andrews, UK.
H R StaggDepartment of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
D J SloanInfection and Global Health Department, School of Medicine, University of St Andrews, St Andrews, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundMultimorbidity (i.e., the co-existence of two or more long-term health conditions [LTCs]) is increasing in high-TB-burden countries. Few studies have estimated the prevalence of multimorbidity in patients with TB, and none in TB-HIV. This retrospective cohort study used HIV clinic data from the Infectious Diseases Institute in Kampala, Uganda, to determine the prevalence and patterns of multimorbidity in patients with TB-HIV at the time of TB diagnosis, and its effect on TB treatment outcomes.

methodsAdults living with HIV and diagnosed with TB between 1 January 2014 and 14 November 2024 were included. Clinical, laboratory, and prescription records were used to categorise LTCs. The prevalence and patterns of multimorbidity were examined and their effect on WHO-defined TB treatment outcomes was assessed using regression models.

resultsAmong 993 included patients, 76.1% (95% confidence interval: 73.4%-78.8%) had multimorbidity and 34.3% (31.4%-37.4%) had three or more LTCs. Anaemia (52.1%) and undernutrition (34.3%) were most prevalent. Multimorbidity was associated with a 3.70% (-0.35%-7.74%,

conclusionMultimorbidity was highly prevalent at TB diagnosis in this cohort of people with TB-HIV, highlighting the complexity of care required alongside prescription of anti-TB therapy.

Indexed as

non-communicable diseasetreatment outcomestuberculosisUganda

Identifiers

PMID42866577
PMCPMC13657031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.