ArticleInternational journal of women's health2026
Integrative Single-Cell and Bulk Transcriptomic Profiling Reveals Ferroptosis-Driven Heterogeneity of Ovarian Cancer Epithelial Cells.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Ovarian cancer (OC) is a highly lethal gynecological malignancy characterized by insidious onset and poor prognosis, with limited validated prognostic biomarkers and therapeutic targets. Ferroptosis has been implicated in OC progression. However, most existing ferroptosis-related OC studies are based on bulk transcriptomic data, which fail to resolve the heterogeneity of OC epithelial cells. The relationship between ferroptosis-associated heterogeneity of epithelial cells and the tumor immune microenvironment remains insufficiently characterized at single-cell resolution. Materials and Methods: We integrated the GSE184880 single-cell RNA sequencing (scRNA-seq) discovery cohort, the independent GSE235329 scRNA-seq validation cohort, and bulk transcriptomic data from The Cancer Genome Atlas Ovarian Cancer (TCGA-OV) cohort to analyze epithelial cell subpopulations, ferroptosis activity, differentiation trajectories, and intercellular communication, and to construct a prognostic model. Results: OC epithelial cells were clustered into four subpopulations, which were further stratified into ferroptosis-high (EP_0 and EP_3) and ferroptosis-low (EP_1 and EP_2) groups. Key ferroptosis-associated epithelial patterns were reproduced in the independent GSE235329 scRNA-seq cohort. CellChat analysis identified Conclusion: This study characterizes ferroptosis-associated heterogeneity of epithelial cells in OC at single-cell resolution and identifies candidate prognostic biomarkers and epithelial-immune communication signals that warrant further experimental and clinical validation.
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