ArticleDepression and anxiety2026
Altered Fronto-Cingulate Connectivity During Social Competition and Cooperation in Adolescents With Major Depressive Disorder: An fNIRS Hyperscanning Study.
Article in Depression and anxiety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Major depressive disorder (MDD) in adolescence is characterized by high prevalence (24.3% in China) and social dysfunction, particularly in competitive and cooperative behaviors. This study used fNIRS hyperscanning to explore cortical connectivity alterations during parent-adolescent interactions in adolescent MDD. Methods: Thirty-three MDD adolescents (DD) and 29 healthy controls (HCs) completed competitive/cooperative maze tasks with parents under 52-channel fNIRS. Wavelet coherence analyzed functional connectivity (FC) in prefrontal/motor regions, which provides undirected connectivity estimates. Group × task effects were tested via GLMM and FDR correction. Results: (1) Competition: DD exhibited hyperconnectivity in emotion regulation circuits between right opercular inferior frontal gyrus and left triangular inferior frontal gyrus (rIFGoperc and lIFGtriang, Conclusions: Adolescent MDD involves context-dependent neural deficits in social cognition, suggesting targets for neuromodulatory interventions.
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