Evidence map›Paper›PMID 42866470›Full record

ArticleFrontiers in veterinary science2026

Bovine blood products modulate the effect of ophthalmic antibiotics against common bacterial pathogens in dogs with infectious keratitis.

Helen O Kim, Melissa A Kubai, Levi Brock, Chloe C Stinman, Janelle Gapp, Danyang Zhang, Rachel A Allbaugh

Abstract read
In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Helen O KimDepartment of Veterinary Clinical Sciences, Iowa State University, College of Veterinary Medicine, Ames, IA, United States.
Melissa A KubaiDepartment of Veterinary Clinical Sciences, Iowa State University, College of Veterinary Medicine, Ames, IA, United States.
Levi BrockDepartment of Veterinary Clinical Sciences, Iowa State University, College of Veterinary Medicine, Ames, IA, United States.
Chloe C StinmanVeterinary Diagnostic Laboratory, Iowa State University, College of Veterinary Medicine, Ames, IA, United States.
Janelle GappVeterinary Diagnostic Laboratory, Iowa State University, College of Veterinary Medicine, Ames, IA, United States.
Danyang ZhangDepartment of Veterinary Diagnostics and Production Animal Medicine (Statistics), Iowa State University, College of Veterinary Medicine, Ames, IA, United States.
Rachel A AllbaughDepartment of Veterinary Clinical Sciences, Iowa State University, College of Veterinary Medicine, Ames, IA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial keratitis is a common condition that can result in serious complications including vision impairment and loss of the eye if not treated aggressively. Topical blood products are often utilized concurrently with topical antibiotics for their known anti-collagenolytic properties. These blood products contain albumin that could affect the antibiotic efficacy due to drug-protein binding. In this study, serum and plasma were harvested from 10 healthy bovines, utilizing fresh and frozen (1 month at -20 °C) aliquots for the experiment. Albumin and alpha-2 macroglobulin levels were quantified using species-specific ELISA kits. 30 bacterial isolates (10

Indexed as

alpha-2 macroglobulinantibiotic resistanceantimicrobial susceptibility testingbacterial keratitisblood derivativesminimum inhibitory concentrationsprotein binding

Identifiers

PMID42866470
PMCPMC13656309

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.