ArticleCurrent therapeutic research, clinical and experimental2026
Glucagon enhances subcutaneous insulin absorption: Pilot experiments in pigs.
Article in Current therapeutic research, clinical and experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Delayed subcutaneous (SC) insulin absorption remains one of the major barriers to optimal blood glucose control in people with type 1 diabetes and to the development of a fully automated artificial pancreas with SC insulin delivery. Our recent proof of concept study demonstrated that injecting 0.1 mg glucagon at the SC insulin (NovoRapid®) injection site enhances insulin absorption in a porcine model. Present experiments investigate the pharmacokinetics of Lyumjev®, the fastest-acting insulin currently available, when micro-doses of glucagon are co-injected at the same SC site. Methods: 20 anesthetized pigs were administered 10 IU of Lyumjev® SC. Animals were assigned to either a glucagon group ( Results: Compared with Lyumjev® alone, the addition of glucagon to Lyumjev® was associated with an approximately 21% higher mean C Conclusion: These experiments in pigs suggest that micro-amounts of glucagon, when injected at the same SC site as insulin, may speed up and enhance the early absorption of a single SC insulin bolus.
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