ArticleACS medicinal chemistry letters2026
Fluorinated 4‑Methylideneisoxazolidin-5-ones: Synthesis and Apoptosis-Inducing Antiproliferative Activity.
Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sesquiterpene lactones, featuring an α-methylene-γ-lactone moiety, serve as lead compounds for anticancer drug development. Their nitrogen-containing analogues, namely, 4-methylideneisoxazolidin-5-ones, have attracted special attention for their promising anticancer properties. Installing a fluorine atom at the exocyclic double bond of these analogues is highly desirable for improving metabolic stability, bioavailability, and lipophilicity, yet this has not been achieved to date due to the lack of an efficient synthetic method, representing a major obstacle in drug development. Herein, we report a Ni-(II)-catalyzed [3 + 2] cycloaddition/rearrangement cascade reaction of
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