Evidence map›Paper›PMID 42866422›Full record

ArticleACS medicinal chemistry letters2026

Structure-Based Drug Design of Quinoline CYP8B1 Inhibitors for the Potential Treatment of Metabolic Disease.

Amy Bittner McCracken, Derun Li, John P Caldwell, Claire Lankin, Jayaram Tagat, Tanweer Khan, Ashwin Rao, Tianyuan Zhang, Mary Ann Caplen, Andreas Verras and 15 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Amy Bittner McCrackenMerck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0009-0003-8216-0269
Derun LiMerck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0000-0003-0512-6684
John P CaldwellMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Claire LankinMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Jayaram TagatMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Tanweer KhanMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Ashwin RaoMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Tianyuan ZhangMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Mary Ann CaplenMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Andreas VerrasMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Peter OrthMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Alan HruzaMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Thu HoMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Samantha AllenMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Nathaniel L ElsenMerck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0000-0003-1192-7242
Karen DingleyMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Ruth DuffyMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Thomas WisniewskiMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Bethann MurphyMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Jose Castro-PerezMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Kenny WongMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Eric StreckfussMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Jinchu LiuMerck & Co., Inc., Rahway, New Jersey 07065, United States.
Weidong TongMerck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID https://orcid.org/0000-0003-2715-2218
Brian McKittrickMerck & Co., Inc., Rahway, New Jersey 07065, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CYP8B1 has been identified as a potential target for the treatment of metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). CYP8B1 enzyme inhibitor

Indexed as

CYP8B1 inhibitormagic methylmetabolic stabilitynonalcoholic fatty liver disease (NAFLD)structure-based drug design (SBDD)type 2 diabetes (T2D)

Identifiers

PMID42866422
PMCPMC13656273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.