Evidence map›Paper›PMID 42866404›Full record

ArticleACS medicinal chemistry letters2026

Antibody Hotspot-Centric

Rameshwar U Kadam, Jarek Juraszek, Davide Branduardi, Jeroen van Ameijde, Divita Garg, Jan Vermond, Mandy Jongeneelen, Chan Tang, Ronald Vogels, Maria J P van Dongen and 3 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rameshwar U KadamDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
Jarek JuraszekJohnson & Johnson Innovative Medicine, 2333 CN Leiden, the Netherlands.
Davide BranduardiJohnson & Johnson Innovative Medicine, 2333 CN Leiden, the Netherlands.ORCID https://orcid.org/0000-0002-7542-9122
Jeroen van AmeijdeJohnson & Johnson Innovative Medicine, 2333 CN Leiden, the Netherlands.
Divita GargDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
Jan VermondJohnson & Johnson Innovative Medicine, 2333 CN Leiden, the Netherlands.
Mandy JongeneelenJohnson & Johnson Innovative Medicine, 2333 CN Leiden, the Netherlands.
Chan TangJohnson & Johnson Innovative Medicine, 2333 CN Leiden, the Netherlands.
Ronald VogelsJohnson & Johnson Innovative Medicine, 2333 CN Leiden, the Netherlands.
Maria J P van DongenJohnson & Johnson Innovative Medicine, 2333 CN Leiden, the Netherlands.
Boerries BrandenburgJohnson & Johnson Innovative Medicine, 2333 CN Leiden, the Netherlands.
Robert H E FriesenJohnson & Johnson Innovative Medicine, 2333 CN Leiden, the Netherlands.
Ian A WilsonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.ORCID https://orcid.org/0000-0002-6469-2419

Funding

Exploiting sites of vulnerability on influenza virusesR56AI117675 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WILSON, IAN A · 2015 to 2015
$836k
Exploiting Vulnerability on Influenza VirusR56AI127371 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WILSON, IAN A · 2017 to 2017
$730k
NIAID NIH HHS R56 AI117675NIAID NIH HHS R56 AI127371
6 · The paper itself

Abstract

Here we report the applicability of a hotspot-centric approach for

Indexed as

Antibody hotspotsde novo designfusion inhibitorsinfluenza hemagglutininpeptides

Identifiers

PMID42866404
PMCPMC13656271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.