ArticleTranslational gastroenterology and hepatology2026
Predictive target of portal pressure reduction and clinical significance of the portal vein thrombosis subgroup for hepatic encephalopathy after TIPS in decompensated cirrhosis.
Article in Translational gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Portal pressure reduction magnitude (ΔPVP) is a key hemodynamic indicator during transjugular intrahepatic portosystemic shunt (TIPS) procedures, but its relationship with post-TIPS hepatic encephalopathy remains incompletely understood. This study aimed to determine the optimal intraoperative ΔPVP threshold for predicting post-TIPS hepatic encephalopathy. Methods: A total of patients who underwent TIPS were retrospectively analyzed. The optimal ΔPVP threshold was identified using receiver operating characteristic curve analysis. Results: ΔPVP showed a reverse L-shaped association with post-TIPS hepatic encephalopathy, and a ΔPVP threshold of 20 cmH₂O was identified. Patients achieving ΔPVP ≥ 20 cmH₂O had a lower risk of post-TIPS hepatic encephalopathy, particularly in the absence of portal vein thrombosis (PVT). Conclusions: Intraoperative ΔPVP ≥ 20 cmH₂O may serve as a clinically useful target for patients without PVT. External multicenter validation is required to confirm these findings.
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