ArticleAnnals of vascular diseases2026
Impact of Limb Severity on the Wall Structure of the Great Saphenous Vein and Its Involvement in Vein Graft Patency.
Article in Annals of vascular diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This study aimed to determine pathologically how limb severity in chronic limb-threatening ischemia affects the great saphenous vein (GSV) wall, and whether it influences vein graft patency. Methods: In 89 limbs undergoing infrainguinal bypass with the ipsilateral GSV, the intimal and medial thickness of the residual vein segment was measured. Wound (W), ischemia (I), and foot infection (fI) grades were assessed, with loss of primary graft patency as the endpoint. Results: Primary patency was 72.3% at 1 year and 59.3% at 2 years. Independent factors for patency loss were poor-quality vein (hazard ratio [HR] 3.12), severe W grade (HR 2.63), and cerebrovascular disease. Severe W cases had a thicker intima (56.0 vs. 28.1 μm, P <0.01) and media (310.4 vs. 255.8 μm, P = 0.02) than mild cases; the I and fI grades showed no differences. Between the patency-loss (n = 31) and maintained (n = 58) groups, intimal thickness was similar (51.2 vs. 44.1 μm, P = 0.57), whereas medial thickness differed (349.9 vs. 261.1 μm, P <0.01; area under the curve 0.65). Above versus below a 280-μm medial cutoff, patency was 43.0% versus 75.7% (P = 0.03). Conclusions: Medial thickening of the preplacement GSV, seen with a severe wound grade, may be a critical factor in vein graft failure. (This is a secondary publication of Jpn J Phlebol 2025; 36: 89-97.).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.