Evidence map›Paper›PMID 42866390›Full record

ReviewFrontiers in immunology2026

Macrophage states and immunometabolic adaptation in peritoneal metastases from colorectal cancer.

Weihao Chen, Jiali Wei, Yi Wang, Long Sun, Yang Ye, Kang Sun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Weihao ChenDepartment of Colorectal Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Jiali WeiDepartment of Infectious Diseases, The Third Hospital of Zhenjiang Affiliated to Jiangsu University, Zhenjiang, China.
Yi WangDepartment of Colorectal Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Long SunDepartment of Colorectal Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Yang YeMedical School of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, China.
Kang SunDepartment of Colorectal Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy responses in colorectal cancer peritoneal metastases (CRCPM) are not determined by mismatch repair (MMR) status alone. Most MMR-proficient/microsatellite-stable (pMMR/MSS) tumors have low baseline sensitivity, while MMR-deficient/microsatellite instability-high (dMMR/MSI-H) tumors do not respond uniformly, particularly in patients with ascites. This Mini Review compares evidence across compartments and disease stages: human associations, macrophage-resolved functional studies and interventions altering immunotherapy efficacy in mice. Human ascites and tissue studies identify resident-like and monocyte-associated macrophages, including C1Q

Indexed as

Colorectal NeoplasmsMacrophagesPeritoneal NeoplasmsAnimalsHumansMetabolic ReprogrammingTumor Microenvironmentadoptive cell therapycolorectal cancerimmune checkpoint blockadeimmunometabolismmacrophage statesperitoneal metastasis

Identifiers

PMID42866390
PMCPMC13656091

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.