ArticleERJ open research2026
Lung function change and quantitative computed tomography measurements are associated with prospective frailty.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
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Abstract
Background: Frailty, a state of reduced physiologic reserve, is associated with comorbid lung disease. Its relationship with lung function change over time and with lung computed tomography (CT) measurements is less clear. Methods: COPDGene, a multicentre cohort study, enrolled adults aged 45-80 years with a smoking history of a minimum of 10 pack-years. This study included participants with normal baseline 6-min walk distance (6MWD), spirometry at all three site visits and frailty assessment. The primary exposures were baseline quantitative CT measurements (airway wall thickening (Pi10), log (% emphysema), pulmonary artery (PA) enlargement and the ratio of pulmonary blood volume in vessels with a cross-sectional area <5 mm Results: Of 2354 participants, 1200 (51%) were prefrail and 297 (13%) were frail at the 10-year follow-up. Baseline Pi10, log (% emphysema) and PA enlargement were significantly associated with increased odds of frailty (adjusted ORs, respectively: 1.52 (95% CI 1.30-1.77; p<0.001), 1.38 (95% CI 1.14-1.67; p<0.001) and 2.49 (95% CI 1.41-4.41; p=0.002)), as was lower BV5/TBV, an indicator of pulmonary vascular pruning (OR 0.59, 95% CI 0.48-0.72; p<0.001). Forced expiratory volume in 1 s (FEV Conclusion: In a population with a cigarette smoking history, lung function decline and CT measurements were associated with prospective frailty risk.
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