ArticleJournal of thoracic disease2026
Glycyrrhizic acid attenuates sepsis-induced acute lung injury by regulating macrophage M2 polarization via PRKCD.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: Although glycyrrhizic acid (GA) has anti-inflammatory properties and protein kinase C delta (PRKCD) is involved in sepsis, whether GA alleviates sepsis-induced acute lung injury (SI-ALI) by regulating macrophage polarization via PRKCD remains unclear. This study aimed to investigate the protective effects of GA in SI-ALI and explore the underlying molecular mechanisms, with a focus on macrophage polarization mediated by PRKCD. Methods: A cecal ligation and puncture (CLP) model was used to induce sepsis in mice. GA was administered intraperitoneally at different doses for Results: GA significantly alleviated CLP-induced lung tissue injury and pulmonary edema (W/D ratio: 4.5±0.8 Conclusions: GA exerts anti-inflammatory and lung-protective effects in SI-ALI, and our findings suggest that these effects are associated with PRKCD inhibition and restoration of macrophage polarization balance. These results identify PRKCD as a candidate target and support further investigation of GA as a potential therapeutic strategy for SI-ALI.
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