Thermoregulated photothermal therapy for bone defects using graphene oxide hydrogel with mesoporous silica-derived phase-change nanocapsules.

Qian Zhang, Shuang Zhao, Chenxi Shang, Yanan Jiang, Weiwei Zhang, Shuang Pan

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qian ZhangThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin 150001, China.

Shuang ZhaoThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin 150001, China.

Chenxi ShangThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin 150001, China.

Yanan JiangState Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory-Province Key Laboratories of Biomedicine-Pharmaceutics of China), College of Pharmacy, Harbin Medical University, Harbin 150001, China.

Weiwei ZhangThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin 150001, China.

Shuang PanThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin 150001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical translation of photothermal therapy for bone repair is hindered by the risk of thermal damage to surrounding healthy tissues due to uncontrolled high temperatures. We addressed this by integrating phase change materials (PCMs) into a photothermal platform, developing a hydrogel scaffold with temperature regulation. Polyethylene glycol (PEG) was encapsulated in mesoporous nanosilica (MSNs) to form nanocapsules, achieving 82.5% efficiency. This encapsulation prevents PEG leakage and enhances thermal regulation and bioactivity. Graphene oxide (GO) was integrated into an alginate-chitosan matrix, yielding a GO/chitosan scaffold containing PEG@MSNs nanocapsules. The scaffold exhibits a phase transition at 41.2°C and latent heat of 95.5 J/g. Characterization confirms its physicochemical properties, biocompatibility, and cell affinity meet bone repair requirements.

Indexed as

encapsulationhydrogel scaffoldosteogenesisphotothermal therapythermal control

Identifiers

PMID42866289

DOI10.1016/j.isci.2026.117650

PMCPMC13657222

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.