Evidence map›Paper›PMID 42866281›Full record

ArticleMolecular genetics and metabolism reports2026

New insights into bone pathology through a transcriptomic profiling of an osteoblast model of Gaucher disease.

Eleonora Pavan, Paolo Peruzzo, Maximiliano Ormazabal, Dania Ferino, Emma Cuttini, Martina Cusan, Jessica Biasizzo, Maurizio Scarpa, Michela Bulfoni, Andrea Dardis

Abstract read
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In one paragraph

Article in Molecular genetics and metabolism reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eleonora PavanRegional Coordinator Center for Rare Diseases, University Hospital of Udine, Udine, Italy.
Paolo PeruzzoRegional Coordinator Center for Rare Diseases, University Hospital of Udine, Udine, Italy.
Maximiliano OrmazabalRegional Coordinator Center for Rare Diseases, University Hospital of Udine, Udine, Italy.
Dania FerinoClinical Pathology Division, Department of Laboratory Medicine, University Hospital Friuli Centrale ASUFC, Udine, Italy.
Emma CuttiniRegional Coordinator Center for Rare Diseases, University Hospital of Udine, Udine, Italy.
Martina CusanRegional Coordinator Center for Rare Diseases, University Hospital of Udine, Udine, Italy.
Jessica BiasizzoClinical Pathology Division, Department of Laboratory Medicine, University Hospital Friuli Centrale ASUFC, Udine, Italy.
Maurizio ScarpaRegional Coordinator Center for Rare Diseases, University Hospital of Udine, Udine, Italy.
Michela BulfoniInstitute of Pathology, University Hospital of Udine, Department of Medicine (DMED), University of Udine, Udine, Italy.
Andrea DardisRegional Coordinator Center for Rare Diseases, University Hospital of Udine, Udine, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although up to 90% of Gaucher Disease (GD) patients report bone symptoms, the molecular basis underlying the contribution of osteoblasts in bone pathology remains poorly understood. To identify potential molecular players in this process, we developed and characterized a new model of GD osteoblasts by knocking out (KO) the

Indexed as

Bone pathologyGaucher diseaseOsteoblastsTranscriptional profile

Identifiers

PMID42866281
PMCPMC13657217

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.