Evidence map›Paper›PMID 42866262›Full record

ArticleJournal of thoracic disease2026

The relationship between hemoglobin concentration and mortality in patients receiving venovenous extracorporeal membrane oxygenation support: a single-center retrospective cohort study.

Xinyi Luo, Yin Xi, Jinquan Xie, Zhangwei Liang, Xiaoli Chen, Yuelin Liu, Ying Zhu, Juan Ouyang, Jie Zhang, Weiqun He and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xinyi LuoDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Yin XiDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Jinquan XieDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Zhangwei LiangDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Xiaoli ChenDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Yuelin LiuDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Ying ZhuDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Juan OuyangDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Jie ZhangDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Weiqun HeDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Xiaoqing LiuDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Haibo ZhangDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Yimin LiDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Yonghao XuDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.
Ya WangDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Medical Center for Respiratory Medicine, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Restrictive red blood cell (RBC) transfusion strategies are increasingly used during venovenous extracorporeal membrane oxygenation (VV ECMO), but the prognostic implications of sustained exposure to low hemoglobin concentrations remain uncertain. We investigated the associations of longitudinal hemoglobin exposure with 60-day mortality and successful ECMO weaning in patients receiving VV ECMO. Methods: We retrospectively analyzed adults receiving VV ECMO for at least 48 hours at a single center between January 2015 and May 2024. Patients who were pregnant or had received ECMO for >3 days at an outside hospital before transfer were excluded. Time-weighted average hemoglobin (TWA-Hb) was calculated from serial venous complete blood count measurements by weighting each hemoglobin value according to the time interval represented by that measurement. Patients were categorized as <70, 70-<80, 80-<90, and ≥90 g/L. The proportion of ECMO support time with hemoglobin <70 g/L was calculated as an exploratory measure of cumulative severe-anemia exposure. The primary outcome was 60-day mortality. Results: Among 182 patients, the median age was 59 years, 74.2% were male, and 97.3% received RBC transfusions (median 20 units). Seventy-five patients (41.21%) died within 60 days. Compared with the ≥90 g/L group, TWA-Hb <70 g/L was associated with a higher hazard of 60-day mortality [adjusted hazard ratio (HR) 3.47, 95% confidence interval (CI): 1.00-12.03, P Conclusions: TWA-Hb <70 g/L during VV ECMO was associated with higher 60-day mortality and a lower likelihood of successful ECMO weaning. Sustained exposure to severe anemia below 70 g/L warrants particular clinical attention and should be minimized when feasible. These findings support further prospective evaluation of hemoglobin-management strategies aimed at reducing prolonged severe-anemia exposure during VV ECMO.

Indexed as

anemiahemoglobinprognosistransfusionVenovenous extracorporeal membrane oxygenation (VV ECMO)

Identifiers

PMID42866262
PMCPMC13655916

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