ArticleThe journal of nutritional physiology2026
The Impact of a Western Diet with High Salt on Metabolic Outcomes in Male C57bl/6J Mice.
Article in The journal of nutritional physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The typical Western diet drives obesity and metabolic disease through high intake of saturated fats, sugars, and salt. However, common rodent diet models (High-Fat, High-Sucrose, or HFHS) are often low in salt. We aimed to investigate the chronic metabolic outcomes by feeding C57BL/6J male mice a Low-Fat Diet (LFD), HFHS, or a High-Salt HFHS diet (HFHS + 3% Salt) for 16 weeks, monitoring body composition, glucose tolerance, and tissue function. The HFHS group exhibited the most significant weight gain over 16 weeks. Surprisingly, the addition of salt mitigated hepatic lipid accumulation; the HFHS + Salt group had liver weights and triglyceride levels like the LFD group, while the HFHS group showed elevated levels. However, the high-salt component exacerbated other issues. The HFHS + Salt fed mice displayed the highest degree of glucose intolerance, followed by the HFHS group. Furthermore, gonadal adipose tissue was significantly larger in the HFHS + Salt mice, suggesting the salt component specifically drives expansion in this depot. Paradoxically, salt also appeared to dampen the expression of inflammation-related genes (
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