Evidence map›Paper›PMID 42866249›Full record

ArticleiScience2026

Peroxisome-dependent and -independent functions of PEX19 in mouse embryonic stem cells.

Wei Fan, Yi Fang, Joshua Hartsell, Xiaoyue Wu, Xiaojiang Xu, Jian-Liang Li, Xiaojing Liu, Xiaoling Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei FanMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Yi FangMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Joshua HartsellDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA.
Xiaoyue WuMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Xiaojiang XuIntegrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Jian-Liang LiIntegrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Xiaojing LiuDepartment of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA.
Xiaoling LiMolecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.

Funding

National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
Biomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2M
Investigating the involvement of small intestine in metformin's effect on hepatic lipid metabolismR35GM150985 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Xiaojing Liu · 2023 to 2026
$1.6M
NIDDK NIH HHS U2C DK119886NIGMS NIH HHS R35 GM150985NIH HHS OT2 OD030544
6 · The paper itself

Abstract

Pluripotent embryonic stem cells (ESCs) possess a unique cell cycle pattern to support self-renewal and maintain pluripotency, and remodeling of this cycle by developmental cues is a key priming step for lineage commitment. Here we report an unexpected role of PEX19, a chaperone and receptor for peroxisomal membrane proteins, in regulating cell cycle and cell fates of mouse ESCs (mESCs) through a peroxisome-independent mechanism. We show that deletion of

Indexed as

cell cycleoxidative stressplasmalogenspluripotency exitself-renewal

Identifiers

PMID42866249
PMCPMC13657169

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.