ArticleTranslational pediatrics2026
Native amniotic fluid promotes barrier-associated maturation of the neonatal intestine under physiological conditions.
Article in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The neonatal intestine undergoes dynamic maturation after birth, during which an effective epithelial barrier is essential for intestinal adaptation and function. Amniotic fluid (AF) contains diverse bioactive components that may contribute to intestinal development. This study aimed to investigate whether native AF supports barrier-associated maturation of the neonatal intestine under physiological, non-injury conditions. Methods: Results: Native AF at 25% and 50% increased tight junction protein expression, with the strongest response observed in the 50% AF group (P<0.01). TEER values increased in Caco-2 and IEC-6 monolayers (P<0.001 for 50% AF) and in neonatal rat intestinal tissues, particularly on day 14 (P<0.01 for 50% AF). Permeability to fluorescein isothiocyanate-conjugated inulin decreased significantly in both AF-treated monolayer groups (P<0.001). Intestinal morphology remained unchanged across treatment groups. Conclusions: Native AF increased tight junction protein expression, improved barrier-related properties in epithelial monolayers, and produced early
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