Evidence map›Paper›PMID 42866036›Full record

ArticleFrontiers in physiology2026

Systemic elevation of gut derived

Michael A Schmidt, Caleb M Schmidt, Julian C Schmidt, Cem Meydan, Evan E Afshin, Eliah G Overbey, JangKeun Kim, Ruth Subhash Singh, Afshin Beheshti, Christopher E Mason

Abstract read
In one paragraph

Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael A SchmidtSovaris Aerospace, Boulder, CO, United States.
Caleb M SchmidtSovaris Aerospace, Boulder, CO, United States.
Julian C SchmidtSovaris Aerospace, Boulder, CO, United States.
Cem MeydanDivision of Hematology and Medical Oncology, Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
Evan E AfshinDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.
Eliah G OverbeyDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.
JangKeun KimDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.
Ruth Subhash SinghDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, United States.
Afshin BeheshtiStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, United States.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.

Funding

VAST Center: Viromes Across Space(s) and TimeU54AG089334 · NIA · STANFORD UNIVERSITY · PI Inmaculada de Melo-Martin · 2025 to 2026
$13.3M
Risk Genes and Environment Interactions in NTDsP01HD067244 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROSS, MARGARET ELIZABETH · 2011 to 2020
$12.6M
Project 3: Targeting PRMT5 in Mantle Cell LymphomaP01CA214274 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BALLMAN, KARLA V. · 2018 to 2022
$8.9M
Defining the role of the RNA modification N6-methyladenosine in the hepatitis C virus lifecycleR01AI125416 · NIAID · DUKE UNIVERSITY · PI Stacy Michelle Horner · 2016 to 2026
$5.5M
Clinical and Molecular Heterogeneity in the Myelodysplastic SyndromesR01CA249054 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MASON, CHRISTOPHER EDWARD, PARK, CHRISTOPHER Y · 2020 to 2024
$3.5M
Metagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantationR01AI151059 · NIAID · CORNELL UNIVERSITY · PI DADHANIA, DARSHANA, DE VLAMINCK, IWIJN · 2020 to 2024
$3.4M
The Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3M
NCI NIH HHS P01 CA214274NCI NIH HHS R01 CA249054NIAID NIH HHS R01 AI125416NIAID NIH HHS R01 AI151059NIA NIH HHS U54 AG089334NICHD NIH HHS P01 HD067244NIMH NIH HHS R01 MH117406
6 · The paper itself

Abstract

Introduction: We observed the elevation of Methods: A pair of monozygotic twins were studied for 25 months, during which one subject spent 340 days aboard the International Space Station (ISS), while his identical twin remained on Earth. Molecular analyses included genome, epigenome, transcriptome, proteome, metabolome, immunome, and microbiome. Our metabolite feature extraction was focused on plasma Results: Significance was observed for pCG when comparing Post-flight vs. Inflight (adj p = 0.016). pCS values were significantly altered Post-flight vs. Inflight (adj p = 0.002) and Post-flight vs. Late-flight (adj p = 0.037). pCS values for Early-flight vs. Pre-flight approached significance (adj p = 0.08). In alignment with elevated plasma Discussion: We observed an elevation of

Indexed as

metabolomemicrobiomemultiomicsNASA twins studyp-cresolprebioticsprecision medicinespaceflight

Identifiers

PMID42866036
PMCPMC13655695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.