ArticleMolecular therapy. Nucleic acids2026
Single-cell and intercellular communication analyses reveal DLL3 as a key regulator in the glioma tumor microenvironment.
Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Glioma progression is increasingly recognized as a process driven not only by intrinsic genetic alterations in tumor cells but also by dynamic interactions within the tumor microenvironment (TME). However, systematic insight into the remodeling of intercellular communication networks during glioma evolution and their role in tumor progression remains limited. We integrated large-scale single-cell RNA sequencing with computational inference of ligand-receptor interactions to characterize the cellular landscape and communication architecture across disease stages. Single-cell analysis of normal brain and glioma tissues revealed pronounced cellular heterogeneity and stage-dependent remodeling of the TME, involving malignant cells, immune populations, glial cells, and vascular components. Intercellular communication analysis showed extensive reconstructing and strengthening of signaling networks during glioma progression, particularly among glioma cells, myeloid cells, astrocytes, and endothelial cells. Integrative analysis identified six communication-associated genes (
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