Evidence map›Paper›PMID 42865964›Full record

ReviewFrontiers in medicine2026

Genetic susceptibility and neuroprotective gene therapy of normal tension glaucoma: a review.

Xiaoyu Liu, Dadong Jia, Hao Hu, Liang Liang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaoyu LiuDepartment of Ophthalmology, The Second People's Hospital Affiliated to China Three Gorges University, Yichang Second People's Hospital, Yichang, China.
Dadong JiaDepartment of Ophthalmology, The Second People's Hospital Affiliated to China Three Gorges University, Yichang Second People's Hospital, Yichang, China.
Hao HuDepartment of Ophthalmology, The Second People's Hospital Affiliated to China Three Gorges University, Yichang Second People's Hospital, Yichang, China.
Liang LiangDepartment of Ophthalmology, The Second People's Hospital Affiliated to China Three Gorges University, Yichang Second People's Hospital, Yichang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Normal-tension glaucoma (NTG) is a distinct form of glaucomatous optic neuropathy characterized by progressive retinal ganglion cell (RGC) degeneration and visual field loss despite intraocular pressure (IOP) remaining within the statistically normal range. Although IOP reduction remains the only established disease-modifying strategy, continued disease progression despite adequate IOP control highlights the importance of IOP-independent mechanisms. Increasing evidence implicates vascular dysregulation, mitochondrial dysfunction, oxidative stress, impaired autophagy, neuroinflammation, axonal transport abnormalities, and circadian dysregulation in increased RGC vulnerability. Genetic studies have identified

Indexed as

adeno-associated virusautophagycircadian rhythmgene therapymitochondrial dysfunctionnormal-tension glaucomaoptic nerve protectionvascular dysregulation

Identifiers

PMID42865964
PMCPMC13655583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.