ArticleACS medicinal chemistry letters2026
Next Generation NMR Flow Tube Optimized for Small Volume NMR Reaction Monitoring in Preclinical Drug Discovery.
Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We developed a 3 mm NMR flow tube that can be inserted into a 5 mm NMR probe converting a high field NMR spectrometer into a reaction monitoring system with a minimum reaction volume of 2 mL. The system uses a standard LC pump to flow the reaction mixture from a reaction vial in an integrated heating block to the center of the magnet for detection before returning the mixture back to the vial. The NMR flow tube has a temperature range of -20 to 120 °C and the NMR instrument can be switched from NMR tubes to the flow tube mode in a few minutes. We report the use of this flow NMR small volume system to monitor the progress of two chemical reactions that resisted study by more common analytical techniques.
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