Evidence map›Paper›PMID 42865939›Full record

ReviewFrontiers in pharmacology2026

Bioactive compounds from Perilla frutescens modulate multiple cell death pathways and signaling networks in cancer therapy.

Hai Xu, Jingyi Liu, Huikun Wu, Hussein Sabit, Bangquan Huang, Yong Zhou, Lei Wang, Linhai Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hai Xu *Huangjiahu Hospital, Hubei University of Chinese Medicine, Wuhan, China.
Jingyi Liu *First Clinical College, Hubei University of Chinese Medicine, Wuhan, China.
Huikun WuHuangjiahu Hospital, Hubei University of Chinese Medicine, Wuhan, China.
Hussein SabitDepartment of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza, Egypt.
Bangquan HuangCollege of Life Science, Hubei University, Wuhan, China.
Yong ZhouOncology Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
Lei WangKey Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, China.
Linhai WangKey Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perilla frutescens, an edible medicinal plant from East Asia, produces diverse bioactive phytochemicals with anticancer activity, including perillaldehyde (PAH), rosmarinic acid (RA), luteolin, apigenin, and alpha-linolenic acid (ALA). These compounds exert multi-target anticancer effects through apoptosis, autophagy, and ferroptosis. PAH triggers ferroptosis in gastric cancer via the System Xc-/GSH/GPX4 axis and P62-Keap1-Nrf2 pathway, while inducing protective autophagy in colorectal cancer through SRD5A1 and PI3K/AKT modulation. RA directly binds KRAS(G12C) and suppresses NSCLC via KRAS/AKT/ERK, and inhibits stress-induced TNBC metastasis through Src inactivation.

Indexed as

apoptosisautophagyluteolinPerilla frutescensperillaldehyderosmarinic acid

Identifiers

PMID42865939
PMCPMC13655542

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.