Evidence map›Paper›PMID 42865912›Full record

ArticleDigital discovery2026

Pharmacological stratification of public bioactivity databases: a reusable, OECD-anchored curation and benchmarking framework demonstrated for opioid receptors.

Manal A Nael, Laxman M Alakonda, Abhik Ghosh, Sara Jane Ward, Lee-Yuan Liu Chen, Anjali M Rajadhyaksha, Magid Abou-Gharbia, Khaled M Elokely

Abstract read
In one paragraph

Article in Digital discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Manal A NaelDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University Tanta 31527 Egypt.
Laxman M AlakondaDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wyoming 1000 E. University Ave. Laramie WY 82071 USA kelokely@uwyo.edu +1(307) 766-6136.
Abhik GhoshCenter for Substance Abuse Research, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University Philadelphia PA 19140 USA.ORCID https://orcid.org/0009-0007-0835-7230
Sara Jane WardCenter for Substance Abuse Research, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University Philadelphia PA 19140 USA.
Lee-Yuan Liu ChenCenter for Substance Abuse Research, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University Philadelphia PA 19140 USA.
Anjali M RajadhyakshaCenter for Substance Abuse Research, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University Philadelphia PA 19140 USA.
Magid Abou-GharbiaDepartment of Pharmaceutical Sciences, Temple University School of Pharmacy Philadelphia PA 19140 USA.
Khaled M ElokelyDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wyoming 1000 E. University Ave. Laramie WY 82071 USA kelokely@uwyo.edu +1(307) 766-6136.ORCID https://orcid.org/0000-0002-2394-021X

Funding

Wyoming INBRE Phase 4- Equipment Supplement for x-ray diffractometer for Center for Advanced Scientific InstrumentationP20GM103432 · NIGMS · UNIVERSITY OF WYOMING · PI Nicolas A. Blouin · 2012 to 2026
$56.8M
NIGMS NIH HHS P20 GM103432
6 · The paper itself

Abstract

Public bioactivity databases are heterogeneous not only in measurement type, where binding affinities and functional potencies are reported on different scales, but in pharmacology: the same compound and target can carry agonist, antagonist, or inhibitor records measured through binding displacement, cAMP, β-arrestin, or [

Identifiers

PMID42865912
PMCPMC13656078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.