ArticleChemical science2026
Unlocking catalytic asymmetric transformations of sulfilimidoyl fluorides toward chiral sulfinimidate esters.
He-Ping Li, Ze Zhao, Meng Li, Xuan Jin, Xiang-Hong He, Jin Zhang, Wei Huang, Cheng Peng, Gu Zhan, Bo Han
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In one paragraphArticle in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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He-Ping LiState Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China zhangu@cdutcm.edu.cn hanbo@cdutcm.edu.cn.
Ze ZhaoState Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China zhangu@cdutcm.edu.cn hanbo@cdutcm.edu.cn.
Meng LiState Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China zhangu@cdutcm.edu.cn hanbo@cdutcm.edu.cn.
Xuan JinState Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China zhangu@cdutcm.edu.cn hanbo@cdutcm.edu.cn.
Xiang-Hong HeState Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China zhangu@cdutcm.edu.cn hanbo@cdutcm.edu.cn.
Jin ZhangSchool of Pharmacy, Shenzhen University Medical School, Shenzhen University Shenzhen 518055 China zhangjin1989@szu.edu.cn.
Wei HuangState Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China zhangu@cdutcm.edu.cn hanbo@cdutcm.edu.cn.ORCID https://orcid.org/0000-0003-0832-1864 Cheng PengState Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China zhangu@cdutcm.edu.cn hanbo@cdutcm.edu.cn.ORCID https://orcid.org/0000-0003-3303-906X Gu ZhanState Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China zhangu@cdutcm.edu.cn hanbo@cdutcm.edu.cn.ORCID https://orcid.org/0000-0002-5263-8263 Bo HanState Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137 China zhangu@cdutcm.edu.cn hanbo@cdutcm.edu.cn.ORCID https://orcid.org/0000-0003-3200-4682 Funding
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6 · The paper itselfAbstract
The rational design of bioactive molecules increasingly utilizes sulfur-containing groups such as sulfoximines and sulfilimines. While sulfonimidoyl fluorides have emerged as versatile chiral S(vi) electrophiles enabling efficient asymmetric synthesis of sulfoximines, their S(iv) counterparts, sulfilimidoyl fluorides, have remained inaccessible in asymmetric catalysis due to their intrinsic instability and configurational lability. Central to this strategy is a bifunctional tertiary amine-hydrogen-bond donor catalyst that enables selective conversion of a transient sulfur(iv) intermediate. Mechanistic studies support a dynamic kinetic resolution process involving a sulfilimidoyl fluoride intermediate, providing a distinct strategy for accessing
Identifiers
PMID42865885
PMCPMC13656016
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