ArticleFrontiers in public health2026
Association between frailty and cognitive function in hospitalized older adults: a moderated serial mediation analysis involving functional status, depression, and social support.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to examine whether impaired basic activities of daily living (BADL) and depression accounted for the association between frailty and cognitive function in hospitalized older adults, and whether social support moderated these relationships. Methods: A cross-sectional design was adopted in this study, including hospitalized older adults aged 60 years and above. Data were collected using a digital comprehensive geriatric assessment system, including mini mental state examination (MMSE), frailty scale, BADL scale, geriatric depression scale (GDS), and social support rating scale (SSRS). Hierarchical regression, serial mediation, and moderated mediation analyses were performed using PROCESS macro (Model 92) with 5,000 bootstrap resamples to examine potential statistical pathways from frailty to cognitive function and the moderating role of social support. Results: Among 1,611 hospitalized older adults, frailty was statistically associated with lower MMSE scores. After adjustment for demographic, socioeconomic, and lifestyle-related variables, the direct association was not significant ( Conclusion: The relationship between frailty and cognitive function was mainly characterized by indirect associations involving BADL impairment and depression, with the depression pathway contributing the most statistically. Social support moderated specific associations within this statistical framework. These findings suggest that functional, psychological, and social factors should be considered together in efforts to maintain cognitive health and promote healthy aging among older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.