Evidence map›Paper›PMID 42865743›Full record

ArticleJournal of clinical and translational hepatology2026

Mass Cytometry Reveals Cell Type-specific Immune Remodeling in Placentas of Women with Chronic Hepatitis B Infection.

Zirong Yang, Li Qi, Yang Bai, Weiwei Zhou, Wenjing Wang, Yunxia Zhu, Junfeng Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and translational hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zirong YangFirst Department of Liver Disease, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Li QiDepartment of Infectious Diseases, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Yang BaiFirst Department of Liver Disease, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.
Weiwei ZhouPediatric Department, Beijing You An Hospital, Capital Medical University, Beijing, China.
Wenjing WangBeijing Institute of Hepatology, Beijing You An Hospital, Capital Medical University, Beijing, China.
Yunxia ZhuPhysical Examination Center, Beijing You An Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-1047-7035
Junfeng LuFirst Department of Liver Disease, Beijing You An Hospital, Capital Medical University, Beijing Institute of Hepatology, Beijing, China.ORCID https://orcid.org/0000-0003-0558-6816

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Hepatitis B virus (HBV) vertical transmission remains a major health challenge, and the characteristics of the placental immune microenvironment in chronic infection remain unclear. This study aimed to use mass cytometry to comprehensively analyze phenotypic changes in placental immune cell subsets. Methods: We collected placental tissues from 20 pregnant women (6 healthy controls and 14 with chronic HBV infection). CD45 Results: HBV mainly caused functional remodeling of placental immune cells rather than changes in cell composition ( Conclusions: These exploratory findings suggest that HBV may reshape placental immunity through enhanced NK cell activation, broad basophil suppression, and disrupted marker coordination. The sample size was limited (n = 20), so the results need to be validated in larger cohorts. These findings provide new perspectives for understanding the mechanisms of mother-to-child transmission.

Indexed as

BasophilsChronic hepatitis BHepatitis B virusImmune phenotypingNatural killer cellsPlacentaPregnancyVertical transmission

Identifiers

PMID42865743
PMCPMC13655724

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.