Evidence map›Paper›PMID 42865737›Full record

ArticleFrontiers in aging neuroscience2026

Unraveling changes in mitochondrial processes influenced by ancestry in

M D M Muniz Moreno, K Celis, F Rajabli, P L Whitehead, K L Hamilton-Nelson, D M Dykxhoorn, K Nuytemans, M M Mesulam, D A Bennett, T Schuck and 12 more

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

M D M Muniz MorenoHussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
K CelisHussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
F RajabliHussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
P L WhiteheadHussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
K L Hamilton-NelsonHussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
D M DykxhoornHussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
K NuytemansHussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
M M MesulamNorthwestern ADC Neuropathology Core, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
D A BennettDepartment of Neurological Sciences and Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.
T SchuckThe Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
S WeintraubNorthwestern ADC Neuropathology Core, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
C GeulaNorthwestern ADC Neuropathology Core, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
M GearingGoizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, United States.
C AlbaDepartment of Anatomy Physiology and Genetics, Uniformed Services University, Bethesda, MD, United States.
C L DalgardDepartment of Anatomy Physiology and Genetics, Uniformed Services University, Bethesda, MD, United States.
D A DavisBrain Endowment Bank, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
W K ScottHussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
J L HainesCleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, United States.
M A Pericak-VanceHussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
A J GriswoldHussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
J M Vance *Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.
J I Young *Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, United States.

Funding

Inclusion of sub-group of ASPREE samples into the ADSPU01AG066767 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CUCCARO, MICHAEL L, KUNKLE, BRIAN WILLIAM · 2020 to 2024
$21.9M
Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American AncestriesU01AG084545 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GOLDIE S. BYRD, ANTHONY JOHN GRISWOLD · 2024 to 2026
$14.9M
Genomic Characterization of Alzheimer Disease Risk in Admixed Populations with Native American and Southern European Genetic AncestryR01AG070864 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Margaret A. Pericak-Vance, FARID RAJABLI · 2021 to 2026
$12.1M
Functional genomic studies in diverse populations to characterize risk loci for Alzheimer DiseaseU01AG072579 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DYKXHOORN, DEREK MICHAEL, GRISWOLD, ANTHONY JOHN · 2021 to 2025
$6.9M
Replication and Extension of ADSP Discoveries in African-AmericansU01AG052410 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BEECHAM, GARY WAYNE, BYRD, GOLDIE S. · 2016 to 2020
$5.2M
Identifying Protective Genetic Variants for APOE4RF1AG059018 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI VANCE, JEFFERY MARVIN · 2018 to 2018
$4.4M
The Origins of Alzheimer Disease in Individuals of African AncestryR56AG072547 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BEECHAM, GARY WAYNE, BYRD, GOLDIE S. · 2021 to 2021
$3.0M
Genomic, Epigenomic, and Transcriptomic Mechanisms of Contributing to Alzheimer's Disease Risk in Diverse Ancestral PopulationsR01AG070935 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BUSH, WILLIAM S, GRISWOLD, ANTHONY JOHN · 2024 to 2025
$1.5M
NIA NIH HHS R01 AG070864NIA NIH HHS R01 AG070935NIA NIH HHS R56 AG072547NIA NIH HHS RF1 AG059018NIA NIH HHS U01 AG052410NIA NIH HHS U01 AG066767NIA NIH HHS U01 AG072579NIA NIH HHS U01 AG084545
6 · The paper itself

Abstract

Introduction: The Methods: Single nuclei RNA sequencing was performed on frontal cortex from 17 AD patients homozygous for Results: Multiple cell types and biological processes contribute to the differences in Conclusion: Our snRNA-seq analysis demonstrates that ancestry-linked regulation of

Indexed as

Alzheimer diseaseancestryAPOEmitochondriasingle cell transcriptome

Identifiers

PMID42865737
PMCPMC13655079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.