ArticleFrontiers in nutrition2026
Caregiver burden and malnutrition in patients with HIV-associated lymphoma: indirect pathways via symptom distress and family closeness, and a test of resilience as a mediator.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective: Malnutrition is a frequent and clinically significant complication in patients with HIV-associated lymphoma, adversely affecting treatment tolerance, prognosis, and quality of life. Although disease-related and immunological determinants of malnutrition have been widely reported, the potential psychosocial pathways-particularly the role of caregiver burden-in patients with HIV-associated lymphoma remain insufficiently characterized. This study aimed to identify key determinants of malnutrition and to examine whether caregiver burden exerts indirect effects through symptom distress and psychosocial factors. Methods: This single-center cross-sectional study included 200 patients with HIV-associated lymphoma and their family caregivers. Nutritional status was assessed using the Patient-Generated Subjective Global Assessment (PG-SGA), with the total score analyzed as a continuous outcome. Symptom burden, caregiver burden, psychological resilience, and family closeness were assessed using standardized instruments. Univariable and multivariable linear regression analyses were conducted using HC3 heteroscedasticity-consistent inference. Indirect statistical associations were examined using bootstrap analyses, followed by exploratory subgroup and sensitivity analyses. Results: Higher symptom burden and IPI risk were associated with higher PG-SGA total scores, whereas higher CD4 + T-cell counts and serum albumin concentrations were associated with lower scores (all Conclusion: Nutritional status in patients with HIV-associated lymphoma was associated mainly with symptom burden, immune status, serum albumin, and lymphoma prognostic risk. Caregiver burden showed neither an independent association with PG-SGA score nor a confirmed indirect association through symptom burden. Larger multicenter longitudinal studies are needed to clarify the temporal relationships among caregiver burden, psychosocial factors, and nutritional status.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.