Potential causal associations between adiposity and hydration status in children and adolescents: evidence from negative control and Mendelian randomization analyses.

Yuwei Hou, Shuying Luo, Kaijuan Wang, Dazhong Wang, Yaodong Zhang

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Yuwei HouHenan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China.

Shuying LuoHenan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China.

Kaijuan WangDepartment of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.

Dazhong WangHenan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China.

Yaodong ZhangHenan Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study examined the potential causal association between body mass index (BMI), waist circumference (WC), and hydration status among children and adolescents. Methods: Participants aged 6-18 years were recruited from 10 cities in Henan Province, China, using a three-stage cluster random sampling strategy. BMI Results: A total of 11,935 children and adolescents (mean age 9.98 ± 2.17 years; 47.6% girls) were included. Both BMI Conclusion: Higher standardized BMI and WC were associated with an increased risk of inadequate hydration, with negative control and MR analyses providing supportive evidence for potential causality, while reverse causality remains uncertain.

Indexed as

body mass indexchildren and adolescentshydration statusMendelian randomizationwaist circumference

Identifiers

PMID42865415

DOI10.3389/fnut.2026.1925090

PMCPMC13654732

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