Observational studyFrontiers in endocrinology2026
Laboratory-based case finding using phosphate and alkaline phosphatase to identify genetic and nutritional rickets in children.
Observational study in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Hypophosphatemic rickets is a rare disease characterized by renal phosphate loss, leading to chronic hypophosphatemia, elevated alkaline phosphatase, and skeletal symptoms that may remain unnoticed until advanced stages. Early diagnosis is essential because effective treatment is available to reduce complications. Objectives: To evaluate a laboratory-based case-finding strategy for identifying oligosymptomatic patients with hypophosphatemic rickets using phosphorus and alkaline phosphatase results in a pediatric population. Methods: A descriptive observational study was conducted in patients under 18 years of age at a tertiary care hospital between June 2021 and July 2025. Of 47,127 phosphorus or alkaline phosphatase measurements requested, 45,923 measurements corresponding to 28,045 tests from 12,513 patients were analyzed after exclusions. Test showing hypophosphatemia and/or elevated alkaline phosphatase were identified, and X-rays and clinical data were reviewed for classification. Results: A total of 22,860 phosphorus measurements and 23,063 alkaline phosphatase measurements were analyzed, with both parameters available in 17,878 laboratory tests. Hypophosphatemia was observed in 2,281 phosphorus measurements (9.98%), and elevated alkaline phosphatase in 3,301 measurements (14.3%). Fifty-five laboratory tests (0.31%) from 37 patients simultaneously met the criteria for hypophosphatemia (<-2 SD) and elevated alkaline phosphatase (>+2 SD); 56.8% were male, with a mean age of 6.5 ± 6.0 years. Following clinical review, 15 patients (40.5%) were classified as having a bone mineral metabolism disorder, including 10 with osteopenia of prematurity, three with nutritional rickets, one with a pathogenic variant in Conclusions: Laboratory-based case finding using phosphorus and alkaline phosphatase may help identify pediatric bone metabolism disorders, including forms of rickets. Combined hypophosphatemia and elevated alkaline phosphatase may be useful for guiding etiological investigation. This approach may complement clinical evaluation and facilitate earlier diagnosis. Early identification is clinically relevant because treatments can modify disease course and reduce long-term complications in children with confirmed forms of rickets, when appropriate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.