Evidence map›Paper›PMID 42865388›Full record

ArticleFrontiers in medicine2026

Two cases of large cell neuroendocrine carcinoma of the gallbladder: case reports and systemic literature review.

Yan Yang, Chunmei Zhang, Qi Liu, Wenyan Lin, Zhengjin Li, Lixian Zhao, Yun Pan

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yan YangClinical Medical College, Dali University, Dali, Yunnan, China.
Chunmei ZhangDepartment of Pathology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China.
Qi LiuClinical Medical College, Dali University, Dali, Yunnan, China.
Wenyan LinClinical Medical College, Dali University, Dali, Yunnan, China.
Zhengjin LiDepartment of Pathology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China.
Lixian ZhaoDepartment of Pathology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China.
Yun PanDepartment of Pathology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As gallbladder large cell neuroendocrine carcinoma (GB-LCNEC) is extremely rare and highly aggressive, with limited reports in both domestic and international literature, we herein report two cases of GB-LCNEC accompanied by contiguous high-grade intraepithelial neoplasia of the overlying mucosa. One of the patients had pancreaticobiliary maljunction. Microscopically, the tumor cells were large and arranged in organoid, nested, palisading or trabecular patterns. They exhibited abundant cytoplasm, vesicular nuclei with coarse granular chromatin, prominent nucleoli, and mitotic figures exceeding 20 per 2 mm

Indexed as

gallbladdergallbladder neoplasmlarge cell neuroendocrine carcinomaneuroendocrine carcinomapancreatobiliary maljunction

Identifiers

PMID42865388
PMCPMC13654770

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.