Evidence map›Paper›PMID 42865362›Full record

ArticleFrontiers in immunology2026

Ameliorative effects and mechanisms of paeonol against rosacea through network pharmacology and experimental validation.

Manyu Chen, Yueye Xu, Xinyu Li, Jingang Xu, Boya Xu, Tingting Zhang, Yujun Shuai, Yao Zhang, Qingquan Chang, Xiaoniu Tang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Manyu Chen *Department of Medical Parasitology, Wannan Medical University, Wuhu, China.
Yueye Xu *Department of Medical Parasitology, Wannan Medical University, Wuhu, China.
Xinyu LiDepartment of Medical Parasitology, Wannan Medical University, Wuhu, China.
Jingang XuDepartment of Medical Parasitology, Wannan Medical University, Wuhu, China.
Boya XuSchool of Public Health, Wannan Medical University, Wuhu, China.
Tingting ZhangSchool of Public Health, Wannan Medical University, Wuhu, China.
Yujun ShuaiDepartment of Medical Parasitology, Wannan Medical University, Wuhu, China.
Yao ZhangSchool of Basic Medical Sciences, Wannan Medical University, Wuhu, China.
Qingquan ChangSchool of Clinical Medicine, Wannan Medical University, Wuhu, China.
Xiaoniu TangDepartment of Medical Parasitology, Wannan Medical University, Wuhu, China.
Jinhong ZhaoDepartment of Medical Parasitology, Wannan Medical University, Wuhu, China.
Yuanyuan LiDepartment of Medical Parasitology, Wannan Medical University, Wuhu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rosacea is a long-term and relapsing inflammatory skin disorder resulting from dysfunction of the immune and/or neurovascular systems. Paeonol (Pae), the primary active component extracted from Moutan Cortex, exhibits various pharmacological effects, including anti-inflammatory and antioxidant properties. This study aimed to evaluate the therapeutic efficacy of Paeonol in treating rosacea and to investigate the underlying mechanisms of its action. Bioinformatics analysis was employed to assess the overlap between rosacea pathogenesis and the pharmacological targets of Pae. An LL-37-induced rosacea-like mouse model was established to evaluate the therapeutic effects of Pae

Indexed as

AcetophenonesAnti-Inflammatory AgentsRosaceaAnimalsCalgranulin BDisease Models, AnimalHumansMiceNetwork PharmacologyNF-kappa BSignal TransductionSkinAcetophenonesAnti-Inflammatory AgentsCalgranulin BNF-kappa BpaeonolLL-37NF-κBpaeonolrosaceaS100A9

Identifiers

PMID42865362
PMCPMC13654719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.