ReviewSe pu = Chinese journal of chromatography2026
[Development of high-performance chromatographic materials and their application in herbalome research since 2020].
Review in Se pu = Chinese journal of chromatography, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Traditional Chinese medicine （TCM）， a treasured cultural heritage of the Chinese nation， plays a significant role in treating various diseases. However， the extreme complexity of its chemical components makes the comprehensive elucidation of the material basis and pharmacological mechanisms a major challenge in modern TCM research. To deeply investigate the material basis of TCM and interpret its holistic regulation mechanism involving multiple components and targets， Liang Xinmiao and his colleagues proposed the concept of herbal materiomics， which focuses on two main research directions： the material basis （including qualitative/quantitative analysis and isolation of active compounds） and the functional mechanisms （in-depth study of biological effects and modes of action）. In herbalome research， chromatographic analysis and preparative purification are powerful tools for deciphering the composition of complex TCM systems， with the development of novel chromatographic separation materials being a key driver of progress. This review systematically summarizes recent advances in the development of novel high performance chromatographic separation materials since 2020 and their applications in herbalome research. It focuses on three chromatographic modes： reversed-phase liquid chromatography （RPLC）， hydrophilic interaction liquid chromatography （HILIC）， and supercritical fluid chromatography （SFC）. The structural and performance characteristics of these novel materials are highlighted， along with their applications in the analysis and preparative purification of key active components such as alkaloids， flavonoids， saponins and terpenoids. In RPLC， the separation selectivity and retention capacity of the stationary phases for compounds such as alkaloids and flavonoids have been effectively enhanced through two primary strategies： first， by incorporating polar groups such as fluorine atoms， amides， carboxyl groups into the traditional C18/C8/phenyl skeletons； second， by utilizing natural product derivatives like cardanol and rosin as functional ligands. Furthermore， this approach has led to the creation of novel materials possessing orthogonal separation characteristics. In HILIC， various functionalized stationary phases have been developed， including
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