ArticleClinical and translational medicine2026
Radiation-induced AXL upregulation in CCR2
Ying-Yi Li, Jian-Qi Xiong, Zhi-Hui Zhang, Xin Liu, Yi-Xin Cheng, Yong-Xin Chi, Guan-Qiao Li, Wen-Huan Zhong, Shuang Chen, Zhen-Yu He
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In one paragraphArticle in Clinical and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Ying-Yi Li *Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Centre for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Centre, Guangzhou, China.
Jian-Qi Xiong *Department of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhi-Hui Zhang *Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Centre for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Centre, Guangzhou, China.ORCID https://orcid.org/0000-0001-8777-0646 Xin Liu *Department of Medical Oncology, Institute of Precision Medicine, Centre for Translational Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yi-Xin Cheng *Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Centre for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Centre, Guangzhou, China.ORCID https://orcid.org/0000-0003-4545-5829 Yong-Xin ChiAffiliated Hospital of Guangdong Medical University & Zhanjiang Key Laboratory of Zebrafish Model for Development and Disease, Guangdong Medical University, Zhanjiang, China.
Guan-Qiao LiDepartment of Breast Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Medical University), Haikou, China.
Wen-Huan ZhongDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Centre for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Centre, Guangzhou, China.
Shuang ChenDepartment of Medical Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhen-Yu HeDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Centre for Cancer, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Centre, Guangzhou, China.ORCID https://orcid.org/0000-0003-1402-8963 Funding
Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515010086China Postdoctoral Science Foundation 2023M734003National Natural Science Foundation of China 82304069Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0502200The Social Development Projects of Key R & D Programs in Hainan Province ZDYF2023SHFZ118
6 · The paper itselfAbstract
backgroundThoracic radiotherapy can cause delayed cardiac fibrosis, but the immune mechanisms linking radiation injury to fibroblast activation remain unclear. We investigated whether CCR2 METHODS AND MATERIALS: C57BL/6 mice received 20 Gy whole-thorax irradiation, and remodelling was assessed from IR_D0 to IR_D60. Bulk RNA sequencing was integrated with single-cell datasets and CIBERSORTx deconvolution, lineage tracing, and tissue staining. CCR2
resultsCardiac fibrosis was established by IR_D30, while leukocyte infiltration and apoptotic signals remained above baseline. Transcriptomic analyses and lineage tracing showed increased cardiac accumulation of CCR2
conclusionsAXL signalling contributes to the fibroblast-activating paracrine activity of cardiac CCR2 KEY POINTS: Radiation exposure induces cardiac fibrosis through immunestromal interactions. CCR2
Indexed as
FibrosisMonocytesProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, CCR2Up-RegulationAnimalsAxl Receptor Tyrosine KinaseMaleMiceMice, Inbred C57BLAxl Receptor Tyrosine KinaseAXL receptor tyrosine kinase, mouseCcr2 protein, mouseProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, CCR2AXLCCR2+ monocytesfibroblast activationMEK/ERK signallingradiation‐induced cardiac fibrosis
Identifiers
PMID42865139
PMCPMC13659278
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