ArticleChemistry & biodiversity2026
Integrating Structural Characterization, Network Pharmacology, and Experimental Validation Reveals the Anti-Liver Aging Mechanism of Acorus tatarinowii Polysaccharides.
Yikuan Du, Jiahui Li, Yuting Lin, Jiawen Luo, Weien Zhang, Feng Chen, Zhonghan Liang, Jiaxin Zhu, Jiaqi Li, Chenyue Yuan and 9 more
Abstract read
In one paragraphArticle in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
19 authors.
Jiahui Li *Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0004-2375-6035 Yuting Lin *Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0000-3117-9523 Jiawen LuoDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0005-0332-892X Weien ZhangDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0005-4885-830X Feng ChenDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0006-1705-4584 Zhonghan LiangDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0009-9128-702X Jiaxin ZhuDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0004-2361-9698 Jiaqi LiDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0004-5139-3411 Chenyue YuanDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0007-3212-527X Yidian LiuDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0009-8429-5339 Xuan LiuDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0000-7836-2296 Yang ZhangDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0002-3008-077X Qiaohong ZhongDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0000-5030-1635 Yanling JiangDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0003-7070-0192 Songsong YangDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0009-0006-0853-7998 Chun YangDongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.ORCID https://orcid.org/0000-0001-5813-0914 Funding
2025 Guangdong Medical University Clinical-Basic Science Innovation Special Program GDMULCJC20252232025 Guangdong Medical University Clinical-Basic Science Innovation Special Program GDMULCJC2025229Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project JDXM2024071FGuangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project JDXM2024136Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project JDXM2024158Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project JDXM2024183Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project JDXM2024190Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project JDXM2025034Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project JDXM2025083Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project JDXM2025115Guangdong Medical University Undergraduate Innovation and Entrepreneurship Education Base Project JDXM2025190Guangdong Provincial Science and Technology Innovation Strategy Special Project (College Students' Science and Technology Innovation Cultivation Project) pdjh2025bk103The Guangdong Basic and Applied Basic Research Foundation 2025A1515012615The Guangdong Medical University Students' Innovation and Entrepreneurship Training Program GDMU2024088The Guangdong Medical University Students' Innovation and Entrepreneurship Training Program GDMU2024114The Guangdong Medical University Students' Innovation and Entrepreneurship Training Program GDMU2024130The Guangdong Medical University Students' Innovation and Entrepreneurship Training Program GDMU2024193The Guangdong Medical University Students' Innovation and Entrepreneurship Training Program GDMU2024232The Guangdong Medical University Students' Innovation and Entrepreneurship Training Program GDMU2025006The Guangdong Medical University Students' Innovation and Entrepreneurship Training Program GDMU2025127The Guangdong Medical University Students' Innovation and Entrepreneurship Training Program GDMU2025174The Guangdong Medical University Students' Innovation and Entrepreneurship Training Program GDMU2025218The Provincial and National College Students' Innovation and Entrepreneurship Training Program 202610571006The Provincial and National College Students' Innovation and Entrepreneurship Training Program S202510571092
6 · The paper itselfAbstract
Liver aging is critical in chronic liver disease progression and systemic aging. Certain polysaccharides from traditional Chinese medicine have attracted increasing interest for their potential to delay liver aging. Acorus tatarinowii exhibits significant hepatoprotection, and its polysaccharides are key bioactive components against aging-related inflammation. However, the mechanism by which Acorus tatarinowii polysaccharides (ATP) protect against liver aging remains poorly understood. The structural features of ATP were characterized, and network pharmacology and bioinformatics were employed to predict key targets and pathways. Furthermore, the hepatoprotective effects of ATP were evaluated in D-galactose-induced aging rats. ATP (56.1 kDa) consisted of rhamnose, arabinose, galactose, glucose, xylose, and galacturonic acid. 272 potential targets were identified. Functional enrichment suggested that these targets were mainly involved in inflammatory response, oxidative stress, Toll-like receptor signaling, and the Keap1-Nrf2 pathway. WGCNA and machine learning identified TLR4 and Nrf2 as potential key targets. In vivo experiments showed that ATP significantly alleviated hepatic atrophy and steatosis, suppressed hepatic TLR4, NF-κB, and HO-1 expression, and activated Nrf2 expression. These findings suggest that ATP ameliorates liver aging, and its hepatoprotective effect is correlated with the regulation of the TLR4/NF-κB and Nrf2 pathways, indicating its potential as a natural anti-aging agent for liver protection.
Indexed as
Network PharmacologyOxidative StressPolysaccharidesAcorusAnimalsLiverRatsRats, Sprague-DawleySignal TransductionPolysaccharidesAcorus tatarinowii polysaccharidesinflammatoryliver agingnetwork pharmacologyoxidative stressstructural characterization
Identifiers
PMID42864957
PMCPMC13659035
What OpenQuestion holds
Textmetadata
Read underepoch 390